Exploring the biological basis of self- non-self recognition by the immune system

Exploring the biological basis of self- non-self recognition by the immune system

Accumulating data, including those coming from the lab of Nathan Karin, suggests that immunological tolerance to self-components is largely maintained by two types of regulatory T cells that suppress the activity of effector T cells, that in these diseases attack self components. The group of Nathan Karin explores the activity of these cells and its regulation in these diseases (for a key recent publication see Meiron et al JEM 2008) and also of a newly defined subset of cells that also suppresses these cells (see Wildbaum, Zohar and Karin Amer. J. Patol 2010).