Genetic basis of auto-inflammatory diseases

The group of inflammatory disorders in which the immune system attacks the body own tissues, has been recently majorly revised and re-categorized into two major subtypes; autoimmune diseases in which cells of the specific arm of the immune system (i.e T cells and B cells) direct the autoimmune attack, and those driven directly by the innate pro-inflammatory cytokines due to genetic or acquired clinical entities resulting in the aberrant release of the pro-inflammatory cytokines. In collaboration with leading physicians from the Mayer Children hospital of RAMBAM medical center, and CARMEL medical center the lab of Nathan Karin focuses on identifying the genetic basis of several auto inflammatory diseases and on developing novel personalized based therapies for these diseases.