Immunological tolerance and regulatory T cells

Immunological tolerance and regulatory T cells

Distinct CXCR3 ligands differentially activate STAT-dependent CD4+ T-cell polarization and regulate experimental autoimmune encephalomyelitis.

2012 Zohar, Y., Barsheshet, Y., Netze, N., Wildbaum, G. & Karin, N. (Submitted) (2012)
The manuscript defines a novel chemokine that regulates the biological functions of FOXp3- CD4+ of inflammatory.

Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17.

2010 Wildbaum, G., Zohar, Y. & Karin, N. Am J Pathol 176, 2764-2775 (2010).
The manuscript defines a novel chemokine that regulates the biological functions of effector TH17 CD4+ of inflammatory autoimmune diseases.

CXCL12 (SDF-1{alpha}) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells.

2008 Meiron, M., Zohar, Y., Anunu, R., Wildbaum, G. & Karin, N. J Exp Med 205, 2643-2655 (2008).
This is the very first manuscript that defined anti-inflammatory chemokines that direct the polarization of regulatory T cells.

Coadministration of plasmid DNA constructs encoding an encephalitogenic determinant and IL-10 elicits regulatory T cell-mediated protective immunity in the central nervous system.

2006 Schif-Zuck, S., Wildbaum, G. & Karin, N. J Immunol 177, 8241-8247 (2006).
This manuscript uses a novel technique to select in vivo IL-10high T-regs.

Tr1 cell-dependent active tolerance blunts the pathogenic effects of determinant spreading.

2002 Wildbaum, G., Netzer, N. & Karin, N. J Clin Invest 110, 701-710. (2002).
This is the very first manuscript that defines the role of IL-10high regulatory T cells in inflammatory autoimmunity within the central nervous system